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Solution structure of the isolated histone H2A-H2B heterodimer

Moriwaki, Yoshihito; Yamane, Tsutomu; Ohtomo, Hideaki +6 more

During chromatin-regulated processes, the histone H2A-H2B heterodimer functions dynamically in and out of the nucleosome. Although detailed crystal structures of nucleosomes have been established, that of the isolated full-length H2A-H2B heterodimer has remained elusive. Here, we have determined the solution structure of human H2A-H2B by NMR coupl…