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Structural insights into the mechanism of rhodopsin phosphodiesterase

Ikuta, Tatsuya; Shihoya, Wataru; Sugiura, Masahiro +9 more

Rhodopsin phosphodiesterase (Rh-PDE) is an enzyme rhodopsin belonging to a recently discovered class of microbial rhodopsins with light-dependent enzymatic activity. Rh-PDE consists of the N-terminal rhodopsin domain and C-terminal phosphodiesterase (PDE) domain, connected by 76-residue linker, and hydrolyzes both cAMP and cGMP in a light-dependen…