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Atomic model of the type III secretion system needle

Baker, David; Loquet, Antoine; Sgourakis, Nikolaos G. +8 more

Pathogenic bacteria using a type III secretion system (T3SS) to manipulate host cells cause many different infections including Shigella dysentery, typhoid fever, enterohaemorrhagic colitis and bubonic plague. An essential part of the T3SS is a hollow needle-like protein filament through which effector proteins are injected into eukaryotic host ce…